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A: A concept called set point theory involves our brains telling us how much fat to store

Clinical diagnosis based solely on symptoms is insufficient

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This increases glucose-dependent insulin secretion via glycolytic genes activation in response to hypoxia and growth factors, which elevate the citric acid cycle and intracellular adenosine triphosphate (ATP) concentration, leading to closure of ATP-sensitive potassium channels depolarizing the cell membrane and then to calcium influx and exocytosis of pancreatic -cells insulin-containing vesicles [43]