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The two co-primary endpoints were analyzed independently, requiring statistical superiority for both to demonstrate a significant benefit of semaglutide versus placebo
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C-Reactive Protein (CRP), High Sensitivity (Cardiac Risk Assessment) Insulin-Like Growth Factor I (IGF-I) ACTH, Plasma Estrone, LC/MS/MS Estradiol, Ultrasensitive, LC/MS/MS Sex Hormone binding Globulin, Serum Pregnenolone, LC/MS Homocysteine, Cardiovascular Tri-iodothyronine Free (FT3) Thyroxine Free, Direct Dialysis (FT4) Total Testosterone, Free (Dialysis) Testosterone (calculated) Copper, Serum or Plasma Dehydroepiandrosterone (DHEA-s) Sulfate Cortisol, AM Fibrinogen Activity Hemoglobin (Hgb) A1c Thyroid Peroxidase (TPO) Antibodies Growth Hormone, Serum Prostate-Specific Antigen (PSA), Total Insulin Follicle-stimulating Hormone (FSH) and Luteinizing Hormone (LH) Progesterone, serum Prolactin, serum Thyroid-Stimulating Hormone (TSH) Dihydrotestosterone, LC/MS/MS Reverse Tri-iodothyronine (RT3) Cardio IQ Cholesterol, Total