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Description
Chemogenetic activation of GLP-1R neurons in the ARC, particularly neurons co-expressing POMC and GLP-1R in male mice, significantly suppressed feeding [86,87]

Further research is needed to understand GLP-1RA-induced hypersensitivity mechanisms and to establish evidence-based guidelines for reaction management
A 50-year-old obese woman with dysautonomia, unexplained dyspnea at rest, orthostatic dizziness, fatigue, brain fog, acid reflux, nausea, POTS, hypermobility and headache of post-viral onset

Retatrutide activates three: GLP-1, GIP, and glucagon receptors
Vieira IH, Barros LM, Baptista CF, Rodrigues DM, Paiva IM

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