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The current thinking is that in many people with obesity, that signal exists but isn't getting through loudly enough, a kind of appetite dysregulation

Clinical Trial Evidence: Weight Loss Outcomes Across Dose Ranges In the SURPASS-1 trial, tirzepatide 15 mg weekly produced an average 22.5% body weight reduction over 52 weeks

The Role of Pharmacies and PBMs in the 340B Drug Pricing Program 11.5.1