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Meta-analyses of clinical trials show that GLP-1 RAs, particularly semaglutide, lead to moderate but clinically meaningful reductions in body weight among adolescents with obesity

GLP-1RAs may improve MASLD by modulating the gut-liver axis, with enhanced effects through dietary interventions and microbiome-targeted therapies involving SCFAs and GLP-1 pathways

The Food and Drug Administration approves several of these drugs specifically for chronic weight management because they work so well

Table 2 Major genomic findings in psychotropic-induced metabolic disturbances

found that tirzepatide led to significant dose-dependent reductions in HbA1c levels when compared to a placebo, once-weekly GLP-1RAs, and basal insulin regimens

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