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The aforementioned observation was also accompanied by decreased mean glutamate-induced current densities.Reference Adams, Pei and Sandoval 27 Similarly, GLP-1 RA administration inhibited A142-induced increases in intracellular calcium concentrations in hippocampal slices of Sprague Dawley rats.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Administration of AP-5 and nifedipine, N-Methyl-D-Aspartate (NMDA) receptor antagonists, also inhibited Abeta142-mediated increases in intracellular calcium concentrations

But not everyone will need such a high dose to achieve their weight loss goals
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Most people who are on GLP-1 medications experience at least one side effect
