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While bariatric surgery has been the most effective traditional intervention for weight management, GLP-1 receptor agonists have brought a breakthrough in the treatment of obesity and diabetes.[89] Recent studies suggest that combining GLP-1 agonists with MSTN inhibitors may enhance therapeutic efficacy while mitigating muscle loss, a key side effect of GLP-1 therapy

Impairment of these redox currency systems compromises both antioxidant defense and mitochondrial bioenergetic stability [83]

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea Tel: +82-31-787-7035, Fax: +82-31-787-4051, E-mail: [email protected] Copyright 2024 Korean Endocrine Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

This all supports sustainable weight management and overall well-being

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Gasoyan H, et al

The anti-apoptotic effects were associated with downregulation of Bax, inhibition of caspase-3 activation, and upregulation of B-cell lymphoma-2 (Bcl-2) expression