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In intestinal L-cells, proglucagon is cleaved by prohormone convertase 1/3 (PC1/3) to generate GLP-1, along with other peptides such as GLP-2, oxyntomodulin, and peptide YY

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Choose tirzepatide if: the research endpoint is weight reduction, HbA1c lowering, or adipose tissue-specific metabolic changes

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