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As you lose weight on tirzepatide , your levothyroxine dose may need reduction, so monitor thyroid function regularly during significant weight loss
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GLP-1 drugs such as Ozempic, Wegovy, and Zepbound have transformed obesity treatment, helping millions lose significant weight
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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores
