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N Engl J Med 2024;390:12071217 [DOI] [PubMed] [Google Scholar] 3

Avoid lying down after eating, consider an over-the-counter antacid, and discuss persistent reflux with your provider

Fatigue during tirzepatide treatment often stems from multiple factors simultaneously

Dose reduction attempts should occur only after weight has been stable for several months

Scenario 2: Established patient, routine dose Michael has been on tirzepatide for three months
