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Evidence now warrants a focus on the beta cell itself and how to avoid its dysfunction, which is putatively caused by cytokine-driven inflammation and other stress factors, leading to low insulin-secretory capacity, autoantigen presentation and immune-mediated destruction

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Clinical trials found it can halt the progression of fibrosis or even reverse it

Mechanical complications such as osteoarthritis and sleep apnea are improved by anti-obesity medications-induced weight loss

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