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These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics.

For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview):

Felix says existing semaglutide patients need take no action their next fill will be charged at the new lower price as generic competition arrives in Canada.

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