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In addition, GLP-1 receptor null mice develop glucose intolerance with dysmorphic islets 25

Hernandez, A

Despite these challenges, the eGFR slope has emerged as a clinically meaningful outcome, with evidence indicating a robust renoprotective effect from the combined use of GLP1-RA and SGLT2i

These effects are thought to stem from slowed gastric emptying and changes in gut motility

GLP-1 is involved in the regulation of energy balance (Holst, 2007), and its activation and subsequent binding to the GLP-1R reduces food intake and, consequently, body weight (Turton et al., 1996)

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