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(19) Clinical Studies Two randomized control trials studied the effect of GLP-1 receptor agonists on BMD, bone mineral content (BMC), and osteogenic markers

doi: 10.1038/nm.3009 44 CoskunTSloopKWLoghinCAlsina-FernandezJUrvaSBokvistKBet al

61 GLP-1R activation triggers Gs-protein coupling, elevating cAMP, modulating calcium mobilization, and inducing -arrestin recruitment

Freedman DS, Butte NF, Taveras EM, Goodman AB, Ogden CL, Blanck HM

Among individual drugs, liraglutide has been noted to carry a relatively higher risk of nausea and vomiting
