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eClinicalMedicine 2021;36
Johnson J
Why GLP-1s May Undermine Long-Term Results GLP-1 medications were originally designed to help regulate blood sugar in diabetics, but they are now widely used for weight loss
Clinical trials and observational data show that effective semaglutide therapy typically spans 12 to 24 months for meaningful weight loss plateaus
Subtle toxicities (like mitochondrial stress, hepatocellular changes, or rare vascular events) may manifest only over time
