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Conclusion PWS is a complex disorder, and this syndromic obesity predisposes to an early risk of developing several health conditions as cardiometabolic diseases

GLP-1RA intervention was associated with a reduction in WHR when compared to those given metformin or placebo (MD = 0.03

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Thus, preference should be given to molecules with the highest potency, such as semaglutide and dulaglutide, over those with lower potency, like exenatide

However, the collected body of evidence does not fully support its clinically relevant antidepressant benefit [165]