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Health Technol Assess 2018;22:1-246

Water and sweat can loosen the patch, and patch ingredients may be unsafe during physical activity

Tolerance development While there is potential to develop tolerance for gastrointestinal side effects over time, this demands consistent adherence and careful dose titration

GLP- 1 receptor activation has longer-term consequences, such as increased b cell proliferation and neogenesis along with cytoprotective (non-insulinotropic) effects [45,46,47,48,49,50,51]

The demand of peptide-based therapies for obesity is projected to increase substantially [18]
