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This study aimed to critically assess the existing literature on the adverse effects of GLP-1 RAs to formulate appropriate risk-benefit prescription practices for their optimal utilization as metabolic disease therapeutics

doi:10.1016/j.bioorg.2020.104492 17

Increasing investments in metabolic disease research, expanding clinical development programs, and continuous advancements in small-molecule drug discovery technologies are further accelerating market growth

Neurogastroenterol Motil 2010;22:664-e203.ArticlePubMed 26

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The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]