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Beyond these acute high-risk combinations, the broader context of polypharmacy in psychiatric care introduces additional layers of complexity, particularly concerning treatment discontinuation

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22 GLP-1 is primarily synthesized in the L cells of the intestinal mucosa, in the cells of pancreatic islets, and in some neurons of the nucleus of the solitary tract (NTS)

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The same study also illustrated that upregulation of GLP-1 via gene transfer was associated with enhanced learning and memory, providing evidence of the role GLP-1 has in hippocampal function [57]

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