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Beyond these acute high-risk combinations, the broader context of polypharmacy in psychiatric care introduces additional layers of complexity, particularly concerning treatment discontinuation
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22 GLP-1 is primarily synthesized in the L cells of the intestinal mucosa, in the cells of pancreatic islets, and in some neurons of the nucleus of the solitary tract (NTS)

The same study also illustrated that upregulation of GLP-1 via gene transfer was associated with enhanced learning and memory, providing evidence of the role GLP-1 has in hippocampal function [57]

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