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If your genetic profile indicates stronger appetite drive, your personalized plan may recommend 35+ years of therapy with confidence that you're optimizing your biology rather than guessing

If you have diabetes, you may be able to safely resume your metformin postpartum even while breastfeeding.Metformin is sometimes prescribed off-label for weight loss , so some people may notice modest weight loss when restarting it

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Also, although there is clinical event reduction data at lower doses in diabetics, getting these data at higher doses in obesity will be very important, especially to support insurers paying a substantial part of the cost of this medication. Also important to learn, Neeland said, is that what is not known, and is not able to be known from the STEP program, are whether there are select benefits in patients with excess visceral adiposity as opposed to excess subcutaneous fat where the fat is in the body, is that related to the weight-loss response, and is it, potentially, then related to the CV benefit? Individualized interventions coupled with the right pharmacotherapy are key, though that often involves trial and error, Stanford said

Gastrointestinal adverse events associated with GLP-1 receptor agonists in metabolic dysfunction-associated steatotic liver disease (MASLD): a systematic review and meta-analysis