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T1DM, characterized by a deficiency of circulating insulin due to beta cell dysfunction or failure [21]

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Despite these issues, they were still great sounding amplifiers

The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction

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