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Metformin has a known GI effect that tends toward looser stools in some patients, which can partially offset GLP-1-related constipation

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Microvascular endothelial cells (CMECs) were isolated from neonatal SpragueDawley (SD) rat hearts by the enzyme dissociation to induce hypoxia/reoxygenation (H/R) injury, and GLP-1 analogue liraglutide protected cardial microvascular endothelium from H/R injury by activating PI3K/Akt/survivin pathways (68).Liraglutide-induced PI3K activation was also able to enhance keratinocyte migration and promote wound healing in mice (9)