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Some GLP1 users report mood changes and anxiety, while others feel better than ever

Although the excessive use of certain performance-enhancing drug (PED) classes is associated with clear health risks, current evidence on PED-related cardiovascular (CV) risk is primarily derived from retrospective reports, small cohorts, or illicit use, leaving major gaps in mechanistic understanding and doseresponse relationships in performance enhancement, well-being, and rehabilitation purposes

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This suggests that no dose adjustments should be required when semaglutide is administered concomitantly with these medications.

NAION = non-arteritic anterior ischemic optic neuropathy is a rare cause of blindness and has been reported at higher rates in those taking GLP1s