weight loss drugs other than glp 1 GLP-1: Genetic Variants Related to GLP-1 RA Medications Alarming rise in weight loss

Despite this, the ability of GLP-1 agonists to offer multiple therapeutic effects beyond their primary uses is drawing considerable interest from the medical community

Two classes of prescription medications frequently discussed are the GLP-1 receptor agonists (including Semaglutide, Ozempic, and Wegovy) and the stimulant phentermine

N Engl J Med (2019) 380(4):34757

Of those 161 patients, 16 (10%) experienced recurrent acute pancreatitis after GLP-1 receptor agonist therapy (mean duration 10.8 7.2 months): 6 (38%) were caused by the GLP-1 receptor agonist (as clinically determined by the treating medical team), three (18%) were due to hypertriglyceridemia, two (12%) due to alcohol use, one (6%) due to another oral hypoglycemic agent, one (6%) due to ampulla stenosis, and three (19%) were idiopathic

5 Here we summarized the complex mechanisms of GLP-1RAs and their latest advancements in treating various diseases, such as musculoskeletal inflammation, obesity, cardiovascular diseases, NAFLD, neurodegenerative diseases, and various cancers

Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15