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Description
Unlike GLP-1 agonists that primarily act on the hypothalamus, amylin agonists exert their strongest effects through brainstem area postrema activation and dramatic gastric slowing exceeding that of any other peptide class

doi: 10.1056/NEJMoa1901118 [DOI] [PubMed] [Google Scholar] 83

That gets back to the preclinical and clinical obesity

In patients with T2D who need greater glucose lowering than can be obtained with oral agents, GLP-1 RAs are preferred to insulin when possible

This gives each zone a full month of recovery between injections, more than enough time for complete tissue healing

The maintenance dose strategy explained Maintenance dosing deserves its own deep dive because it represents the middle ground that works for the largest number of patients
