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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

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#TRANSCENDT2D1 trial : A new era in the treatment of #Type2Diabetes The TRANSCEND-T2D-1 trial provides compelling evidence that #retatrutide, a first-in-class triple GIP/GLP-1/glucagon receptor agonist, may redefine expectations for the treatment of Type 2 DM

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In a new Journal of American Chemical Society study, Krishna Kumar, Martin Beinborn, and co-workers from Tufts University unveil the first unimolecular tetra-agonistspeptides that activate GLP-1R, GIPR, GcgR, and Y2R all at once