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When the nutrients subsequently reach the distal gut, direct contact with the L-cells then triggers additional GLP-1 secretion into the circulation (as also reviewed in [320])

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[DOI] [PubMed] [Google Scholar] 73.Schauder P., Brown J.C., Frerichs H., Creutzfeldt W

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However, a systematic review in 2023 found only one phase 2 randomized controlled trial of exenatide versus placebo for IIH, which did demonstrate a significant reduction in ICP at all time points, as well as improved headache and visual acuity (7,8)