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These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema

Reau, MD Improvements in MASH-related noninvasive test parameters were also observed across body weight reduction thresholds in patients receiving semaglutide, as were improvements in fibrosis-related histologic and noninvasive test responses, including change in ELF scores and VCTE

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Soft drinks and meat intake were markedly associated with the increased risks of MASLD (121,122)

Some patients can reduce insulin significantly, but others remain insulin-dependent and use both medications long-term for optimal control

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