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For patients with high risk of developing NAION (e.g., those with diabetes, hypertension) who are taking GLP-1RAs, ophthalmologists may increase vigilance, she said

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Given the different indications, a randomized head-to-head comparison between liraglutide 3.0 mg, daily subcutaneous injection, and semaglutide 1.0 mg, weekly subcutaneous injection has not been done

Authors' Reply , Alimentary Pharmacology & Therapeutics, (2026)

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These symptoms occurred largely during the dose-escalation period, were transient and mild/moderate in severity, and led to drug discontinuation in up to 7% of participants in each active therapy group