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Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team

The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

PlexusDx Precision Peptide Genetic Test identifies variations in key genes like GLP1R rs6923761 and GIPR rs1800437 that influence your likelihood of strong response to GLP-1 therapies, helping personalize treatment selection

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Among patients with pre-existing substance use disorder, GLP-1s were tied to fewer hospitalizations, overdoses and deaths related to substance use