compound glp 1 Novo Nordisk Drops Hims & Hers: Inside the Compounded GLP-1 Crisis Compounded GLP-1s Become Illegal, Price

2024;121:e2415815121

doi: 10.2337/diabetes.53.suppl_3.s26 43 SantilliFSimeonePGGuagnanoMTLeoMMaccaroneMTDi CastelnuovoAet al

Skip alcohol entirely if you're experiencing active GI side effects (nausea, vomiting, diarrhea)

A separate weight-management indication is subject to ongoing MHRA and NICE appraisal processes as of the time of writing

The 2023 phase 2 double-blind, randomized controlled trial evaluating a GLP-1/GIP/glucagon receptor triagonist (retatrutide) in patients with the disease of obesity reported 24.2% weight loss at 48 weeks with 12 mg retatrutide

The conversion guidance that exists for transitioning between other GLP-1 agonists can provide some framework for thinking about dosing during transitions, though no specific tirzepatide-to-retatrutide conversion protocol has been established in clinical literature