![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:
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![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://www.frontiersin.org/files/Articles/721135/xml-images/fendo-12-721135-g001.webp)
According to the researchers findings, patients in the GLP-1 group had about a 2.56 times higher chance of developing NAION a year later compared to those in the DPP-4 group
![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://cdn.drugdiscoverynews.com/assets/image/4648/screenshot-2025-11-03-152640-m.png)
However, when combined with insulin or sulfonylureas, the risk increases substantially
![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://www.mdpi.com/pharmaceuticals/pharmaceuticals-16-00836/article_deploy/html/images/pharmaceuticals-16-00836-g003.png)
doi: 10.1161/01.ATV.12.5.569
![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://cdn2.caymanchem.com/cdn/cms/caymanchem/PublishingImages/Lists/NewsItems/AllItems/Summary%20of%20insulin%20and%20glucagon%20pathways%20in%20glucose%20homeostasis.png)
Koulen P, Malitschek B, Kuhn R, Bettler B, Wssle H, Brandsttter JH
![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://pancreapedia.org/sites/default/files/Figure%202_Williams.png)
The difference is not marginal
![glp-1 physiology Mechanism of action of [25] Frontiers | GLP-1 Receptor Agonists:](https://ars.els-cdn.com/content/image/1-s2.0-S2214750025000137-gr2.jpg)
