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Persistent vomiting (unable to keep fluids down), severe abdominal pain radiating to your back, signs of allergic reaction, or worsening symptoms after week four warrant immediate medical attention

Loos says that the research on nonresponders is still developing but that solving that mystery would help guide clinicians and their patients in selecting treatments

But even someone with a lower BMI who experiences distress, fatigue, or social stigma from their weight deserves care

While semaglutide works incredibly well for some people, explained Amati, who was not involved in the study, its not without its downsides. You should only take it if it has been prescribed to you by a doctor in the context of a multi-disciplinary team that includes psychotherapy, physical activity, and, crucially, dietary advice. She explained why eating a good diet is particularly important: Because semaglutide reduces appetite, unless the individual consumes a healthy, diverse diet, there is a danger they might miss out on important nutrients