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December 2025: Growing integration of GLP-1 therapies in Japan's diabetes clinics and hospitals, driven by increasing obesity-related comorbidities and demand for convenient administration routes

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Diets that rely heavily on refined grains, such as white bread, pasta, and rice, may also contribute to harder stools

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It is worth emphasizing that TGF-, as a regulatory cytokine, participates in the activation of the bone morphogenetic protein (BMP)/Smad signaling pathway while mediating inflammation, which in turn regulates the differentiation and proliferation of osteoblasts, hence facilitating bone formation and restoration (73)