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MN has garnered significant attention as an efficacious and minimally invasive platform for the transdermal delivery of therapeutic agents, enabling efficient transport across the skin barrier while mitigating the risk of substantial dermal trauma [89,90,91]

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These injectable or oral peptide drugs mimic the natural hormone GLP-1, stimulating insulin secretion while inhibiting glucagon release and slowing gastric emptying

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As a consequence, SELECT has raised the evidence threshold that innovators must clear when targeting conditions such as hypertension, dyslipidaemia or heart failure, including the effect size they need to demonstrate to be clinically meaningful and patient relevant