glp-1 receptor agonist atrial fibrillation risk HRS 2026 Insights: Glucagon-Like Peptide-1 Agonists Reduce Independently of Effects on Weight Loss and Survival GLP-1 RAs demonstrate rhythm-protective benefits

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Alimajstorovic Z, Mitchell JL, Yiangou A et al (2023) Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss

Liraglutide enhances the effect of checkpoint blockade in lung and liver cancers through the inhibition of neutrophil extracellular traps

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45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation