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In humans, fasting systemic plasma concentrations of total GLP-1 (including metabolites generated by DPP-4-mediated degradation) are typically in the range of 510 pmol/L and can increase up to 40 pmol/L in response to a meal [236]

Eating enough is essential to avoid nutrient deficiencies and weight loss stalls

The nausea from sublingual drops differs from injection nausea in its timing pattern

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The mechanism of action of GLP-1RA to promote weight loss mainly includes the reduction of fat deposition through regulation of adipose tissue (lipolysis, fatty acid oxidation, and adipocyte differentiation) and the reduction of food intake through the central and peripheral nervous system