maximum weight loss tirzepatide surmount trials once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial Direct Link to JAMA Post

conducted a retrospective study of 42 women with obesity who had used GLP1RAs for six months pre-pregnancy, but with an eight-week withdrawal before pregnancy, compared with women with obesity who chose to manage their weight with diet and exercise, and found that women who had been using GLP1RAs pre-pregnancy had reduced GWG compared to the diet and exercise group [30]

Acknowledgments The authors thank Eli Lilly for their unconditional support

That is an incredibly small injection volume, less than 0.4 mL

People who were previously insulin resistant are most susceptible

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A 2025 meta-analysis by South Valley University found a similar pattern when it pooled the Yale trial with 2 others