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2026 guide: dosing, side effects, timeline & who benefits

The mechanical unloading of joints and reduction in systemic inflammation associated with weight loss may account for the observed improvements

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The resulting dysbiosis and bacterial translocation contribute to the chronic low-grade systemic inflammation of IBS and depression, thus inducing activation of the HPA axis [5]

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Instead of one larger dose once a week, splitting into two smaller doses keeps levels more stable across the week
