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Slowing the semaglutide dose titration schedule or temporarily reducing the dose can improve tolerability

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(AWARD-6) 3 A 26-week, randomized, open-label, parallel-group, multicenter (62 sites), multinational (9 countries), phase 3, noninferiority study

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Study drugs were provided by AstraZeneca AB, Sweden (dapagliflozin), and Novo Nordisk A/S, Denmark (semaglutide), and Libre Pro glucose sensors were provided by Abbott Diabetes Care, USA, as part of investigator-sponsored study agreements

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Apelin is adipokine expressed in adipocytes, and ovarian cells, and its expression is stimulated by insulin

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Weeks 13-16: Retatrutide 4 mg weekly (hold steady) + Cagrilintide 0.5 mg weekly

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IV hydration therapy is a medical treatment that involves administering fluids, electrolytes, vitamins, and other nutrients directly into the bloodstream via an intravenous (IV) drip

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