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However, no retrospective epidemiological studies can provide definitive answers, and nausea, vomiting and diarrhoea remain the most clinically relevant adverse effects of these drugs, compromising long-term adherence.

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In a new Journal of American Chemical Society study, Krishna Kumar, Martin Beinborn, and co-workers from Tufts University unveil the first unimolecular tetra-agonistspeptides that activate GLP-1R, GIPR, GcgR, and Y2R all at once