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Description
Research suggests that combined GIP and GLP-1 activation produces synergistic rather than merely additive effects on appetite and reward processing

Even with cost as a consideration for some, a dramatic uptick in demand has produced recent shortages, creating barriers for others needing these medicines

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doi: 10.3389/fnut.2025.1538266

10.2337/dc06-1789 [EL 1: MRCT]

However, the use of higher doses for weight loss is an off-label application, meaning it is not specifically approved for this purpose
