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doi: 10.1158/1055-9965.EPI-08-1094 18 McLaughlinSAStaleyACViciniFThiruchelvamPHutchisonNAMendezJet al

These varied treatment responses likely originate from our limited understanding of the mechanisms of weight regulation

Unfortunately, the discussion of the possibilities is far too premature for this article, which focuses on alleviating leptin resistance

Jastreboff and colleagues, in the New England Journal of Medicine, reported that 48 weeks of treatment cut body weight by 8.7 percent at 1 mg, 17.1 percent at 4 mg, 22.8 percent at 8 mg, and 24.2 percent at 12 mg, all once a week under the skin

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And those people are vulnerable and should be treated with respect and care.