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To minimise problems: Sip water regularly and aim for around 2 to 3 litres per day, unless your doctor advises otherwise Consider water rich foods such as soups, cucumbers and watermelon Start with smaller meals, eating slowly and stopping at the first sign of comfortable fullness Focus on softer, easy to digest foods if you feel unwell 4

Metabolic adaptation

Various studies have attempted to quantify how much fat versus muscle mass is being lost when using GLP-1 agonists and the results vary anywhere from 20 to 50% of total weight loss as lean body mass (3) (muscle mass)

31 In a trial evaluating semaglutide for weight loss, the incidence of acute pancreatitis was still low (3 of 1,306 participants) despite a higher dose and more significant weight loss, but none of the 655 individuals in the placebo group developed pancreatitis

As a result, compounded semaglutide may be used when FDA-approved products are unavailable

So, does oral semaglutide work for weight loss