is lemme glp 1 fda approved GLP-1 Drugs from the Gray

Its approved only for treating type 2 diabetes, not for weight loss, according to Drugs.com

Vagal afferent neurons (VANs) expressing GLP-1Rs innervate intestinal mucosa and hepatic portal vasculature, suggesting these pathways may transduce peripheral GLP-1 RA effects to central satiety and glucoregulatory centers 57,58,59

The reality is that every stakeholder has legitimate concerns

128 Our previous data showed that central IR may significantly affect the expression of synaptic plasticity proteins, such as postsynaptic density protein-95 (PSD95), Arc, synapsin1, BDNF, resulting in the impaired synaptic plasticity of neurons and decreased learning and memory ability (data not shown)

10.1016/S0167-0115(99)00089-0 2

This further substantiates the potential of therapies targeting the PYY system in the treatment of obesity