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The chronotropic effect of GLP-1 is independent of beta- and/or alpha-adrenergic blockades To test if the sympathetic nervous system is involved in the GLP-1-induced heart rate increase, we repeated the GLP-1 infusion experiments in the presence of relevant doses of pharmacological blockers of the beta- or alpha-adrenergic receptors after a first (control) GLP-1 dose ( Figure 2 )

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