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Results We included 6 multinational double-blind randomized placebo-control trials that included a total of 52821 T2DM patients

However, no studies have revealed a correlation between the presence of specific bacteria and bile acid concentrations after metformin treatment (Wu et al., 2017)

Detoxification of lipid peroxides relies on glutathione-dependent systems, including GPX4-mediated membrane protection [111]

doi: 10.3109/00365528009181538

Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)

Maintain systemic anti-inflammation: Long-acting agents like semaglutide and tirzepatide sustain anti-inflammatory effects that may deprive malignant cells of supportive inflammatory signals