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Description
Key pharmacological effects include: Glucose-dependent insulin secretion Enhanced pancreatic beta-cell insulin release only when blood glucose is elevated, reducing hypoglycemia risk Suppression of glucagon secretion Decreased hepatic glucose production from pancreatic alpha cells Delayed gastric emptying Slowed movement of food from the stomach to the small intestine Central appetite regulation Reduced hunger and increased satiety through hypothalamic pathways The delayed gastric emptying effect is particularly significant and represents both a therapeutic mechanism and a potential source of adverse effects

Caroline Fontana

Followed for 48 weeks

Blood Pressure-Lowering Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists
This signals a shift in thinking unlike anything weve seen in a generation a move toward treating obesity first, rather than waiting for people to develop the many complications that follow, Arrone said
Give it at least 4-8 weeks of consistent use before evaluating results
