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According to the brand's published materials, NativePath recommends a minimum 90-day consistent use window to assess individual response

This is an important and evolving topic

If you want more context on how plateaus develop and what tends to help, our guide on plateau on GLP-1 weight loss and how to restart is a useful next read

Long-term PPI use (beyond 8-12 weeks) may reduce B12 and magnesium absorption, nutrients already affected by semaglutide's impact on the GI tract

Step 2: Consult with a Licensed Provider

Impact of High Glucose Levels and Glucose Lowering on Risk of Ischaemic Stroke: A Mendelian Randomisation Study and Meta-Analysis