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Description

(Source: National Library of Medicine

Quick Answer: Semaglutide causes diarrhea by activating GLP-1 receptors in the gastrointestinal tract, which alters gut motility, slows gastric emptying, and disrupts normal digestive processes

However, manufacturer assistance programs, insurance coverage, and the Lilly Direct model could bring out-of-pocket costs down to $400 to $600 for many patients

Current Market Pricing (Without Insurance) For context, currently available medications in Canada cost approximately: Wegovy (Semaglutide): $450-550 CAD per month Mounjaro/Zepbound (Tirzepatide): $400-500 CAD per month Saxenda (Liraglutide): $500-600 CAD per month Expected Retatrutide Pricing Eli Lilly typically prices competitively

389 GLP-1RAs and fat metabolism GLP-1RAs work via numerous mechanisms that contribute to weight loss, one of the most well-known of which is the gut-brain axis